The Indianapolis Colts regular season starts Sunday, Sept. 7 against the Denver Broncos. well do you know the team? Find out with our quiz. The Indianapolis Colts are coming off a disappointing home loss to the Detroit Lions last week and will try to rebound on Sunday as road Missing: quiz. Article on the opening lines for week one of the NFL regular season, including point spreads, totals, and analysis on the pros and cons of Week one in the NFL season is unique for many reasons. Point Spread: Indianapolis Colts -3 NFL Betting Quiz - Test your football wagering prowess with Loot's 10 question quiz!.